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・ Mitochondrial membrane transport protein
・ Mitochondrial myopathy
・ Mitochondrial neurogastrointestinal encephalopathy syndrome
・ Mitochondrial optic neuropathies
・ Mitochondrial permeability transition pore
・ Mitochondrial processing peptidase
・ Mitochondrial protein-transporting ATPase
・ Mitochondrial pyruvate carrier 2
・ Mitochondrial ribosomal death-associated protein 3
・ Mitochondrial ribosomal protein L41
・ Mitochondrial ribosomal protein L42
・ Mitochondrial ROS
・ Mitochondrial shuttle
・ Mitochondrial toxicity
・ Mitochondrial translational release factor 1
Mitochondrial trifunctional protein
・ Mitochondrial trifunctional protein deficiency
・ Mitochondrial tRNA pseudouridine27/28 synthase
・ Mitochondrion
・ Mitochondrion (band)
・ Mitocu Dragomirnei
・ Mitocu River
・ Mitoferrin-1
・ Mitogaku
・ Mitogen
・ Mitogen-activated protein kinase
・ Mitogen-activated protein kinase 9
・ Mitogen-activated protein kinase kinase
・ Mitoguazone
・ Mitointeractome


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Mitochondrial trifunctional protein : ウィキペディア英語版
Mitochondrial trifunctional protein

Mitochondrial trifunctional protein (MTP) is a protein attached to the inner mitochondrial membrane which catalyzes three out of the four steps in beta oxidation. MTP is hetero-octamer composed of four alpha and four beta subunits:
* HADHA
* HADHB
The three functions are long-chain 3-hydroxy acyl-coenzyme A dehydrogenase, 2-enoyl coenzyme A (CoA) hydratase, and long-chain 3-ketoacyl CoA thiolase.
==Association with the Electron Transport Chain==
Fatty acid beta-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are two major metabolism pathways in the mitochondria. Reducing equivalents from FAO enter OXPHOS at the level of Complexes I and III. In 2010, Wang et al. discovered a functional and physical association between MTP and ETC respirasomes. Not only does MTP appear to be bound to Complex I, but it also appears to channel substrates between the two enzymes. This is especially interesting, because up until then it was unknown exactly how MTP was associated with the inner mitochondrial membrane, and this discovery may provide the explanation.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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